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The antioxidant fast food was prepared from papaya, guava, banana and betel leaf extract (20:60:15:5 by wt).The food contained low carbohydrate(13.78 g) and ash (0.64 g), while vitamin C(124.48 mg) and potassium(301 mg) contents were very high. Male albino rats were divided into four different groups. The first group was treated as control and administered with standard diet. The remaining three groups were administered with alloxan in divided doses (totalling to 450 mg/kg body wt). The dose of alloxan was finalized after conducting a pilot experiment. The second group was administered with antioxidant diet prepared from fruit pulp and betel leaf extract. The third group was administered with antioxidant and normal diet in the proportion of 1:1. The fourth group was given normal diet. The feeding trial was continued for a period of six weeks and only after seven days of inducing hyperglycemia, weekly monitoring of body weight was carried out. The blood sample was collected, the rats were dissected ,and selected organs (liver, spleen, pancreas, and kidney) were collected. The organs were weighed and histology was performed. Blood sugar level was determined. The alloxan induced hepatic damage and pancreatic disorganization were greatly reduced by the treatment of antioxidant food. The maximum increase in body weight was observed in the fourth group while minimum in the third group. The pancreas showed maximum increase in the alloxan treated group, which was minimized by the antioxidant almost close to normal.
For rapidly increasing human population simultaneously development of modern city life diabetes stretches its paws over the human civilization. According to medical status diabetes is a chronic condition appeared for inefficiency of insulin production by b cells of pancreas insulin-dependant diabetes mellitus (IDDM) or effectively action on target cells non insulin-dependant diabetes mellitus (NIDDM). Statistical report says that around 1.4 million people are affected by diabetes in the UK and more than 18 million Americans have diabetes; about five million do not know they have the disease. It is suspected that if the rate of spread of diabetes continue at its present status, the number of people affected in the United States will increase from about 14 million in 1995 to 22 million in 2025 and in the UK it will reach two million in the year 2010. In the UK for every 100,000 children, around 18 will develop diabetes each year. It is suspected that number of adults with diabetes will rise from 135 million in 1995 to 300 million in the year 2025 worldwide. Experts are reported that around 3.2 million deaths every year are attributable to complications of diabetes; six deaths every minute.
Egyptian physician Hesy-Ra papyrus mentions `polyuria' in papyrus in ancient but first chemical tests developed to indicate and measure the presence of sugar in the urine in early 19th Century. Many research works are performed, more than one core papers are published through the last centuries and those are published in the United Kingdom Prospective Diabetes Study (UKPDS). Importance's of good glucose control and good blood pressure control in the delay and prevention of complications in type NIDDM are clearly identified by UKPDS. Although scientists are prescribed that low calorific fast food for diabetes treatment and to prevent juvenile diabetes but till now there is no such attention on it. An outstanding development in the field of biotechnology is the emergence of a new category of drug, called biopharmaceuticals which is of herbal origin. |
