Various coumarin derivatives have been synthesized by the reaction of acetyl coumarin with different nitro anilines. The structures of all the synthesized products have been confirmed by spectral analysis.

Coumarin derivatives have aroused considerable interest from the viewpoint of their versatile practical application as well as their wide range of biochemical properties (Ghoto and Yamamura, 1948). Coumarin derivatives have been reported for anticoagulant, anti-inflammatory, antimicrobial, anti-HIV, antioxidant, antiallergic, anticancer, antiproliferative and antiviral activities (Mulwad and Shirodkar, 2002; Manohar et al., 2004; Rajeshwar et al., 2004; and Nofal et al., 2000). A series of 7-diethylamino coumarin compounds were synthesized and the cytotoxicities were tested against human umbilical vein endothelial cells (HUVECs) and some cancer cells (Seokjoon et al., 2006). Various substituted coumarins demonstrate a variety of physiological activities (Pacheo and Gotto, 1960; Bragg and Wibbereley, 1961; Moffect, 1964; and Sreenivasulu et al., 1974).

Many structural analogs of acetyl coumarin may be employed as anticoagulants and are mostly used as drugs to control blood clotting. The present paper reports the synthesis of some new coumarin analogs by the reaction of acetyl coumarin with different aromatic amines, characterized using UV, IR and HNMR spectra.

Chemistry Journal, Coumarin Derivatives, Biochemical Properties, Human Umbilical Vein Endothelial Cells, Diethylamino Coumarin Compounds, Anti-proliferative Agents, HNMR Spectra, Human Melanoma Cell, Cancer Cells, UV Spectra, Coumarin Compounds.