Today, entrepreneurship education is essential to improve the process of creating new firms, assuming new risks and rewards. The theoretical discussion around the question: `Entrepreneurs are born or made?' is whether it is possible to educate people to be entrepreneurs. Schools have an important role in this process. Believing in this possibility, our business school developed a set of pedagogical methodologies supported by apprenticeship, based on `learning by doing'. This pedagogical methodology was created through a study of best practices. This study aims to propose a set of innovative methodologies and students perceptions' about their apprenticeship experience/process. The study concludes with a set of recommendations and a best practices manual, useful for appliance in higher education.

The importance of entrepreneurship in the promotion of economic growth, competitiveness and job creation, drew the attention of authorities and companies from across the world. Entrepreneurial activities have greater importance within a knowledge-based world economy. Acting as agents of innovation, entrepreneurs are the key players of the entrepreneurship process.

Since entrepreneurship skills can be developed and improved through people's lives, educational systems, particularly higher education institutions, assume an important role in teaching people to be entrepreneurs, and developing in students essential skills, capabilities and attitudes towards entrepreneurship, which can contribute to entrepreneurial behaviors—both venture creation and intrapreneurship.

Being an entrepreneur implies practice activities. In this context, active pedagogical methodologies must be applied to teach entrepreneurship in the perspective `learning by doing'. Entrepreneurship signature in Setúbal business tries to implement this perspective in their pedagogical model. The paper describes and evaluates this experience.

The FedUni Journal of Higher Education, Entrepreneurship Methodologies, Entrepreneurship Education, Entrepreneurship Skills, Global Entrepreneurship Monitor, Entrepreneurial Risk-taking, European Commission, Decision-Making Process, Business Organizations, Business Plan Development, Human Resources Management, External Resources Availability.